Rationale and design of a randomized clinical trial evaluating the efficacy of mechanical neuroprotection in reducing the risk of silent brain infarcts associated with percutaneous left atrial appendage closure: study protocol for a LAAC-SBI trial.
Witold StrebAnetta Lasek-BalKatarzyna MitręgaJacek KowalczykTomasz PodoleckiWiktoria KowalskaAnna OlmaAgata SobczykZbigniew KalarusPublished in: Trials (2023)
ClinicalTrials.gov NCT05369195. Registration on 11.05.2022.
Keyphrases
- left atrial appendage
- cerebral ischemia
- atrial fibrillation
- phase iii
- study protocol
- resting state
- white matter
- catheter ablation
- brain injury
- phase ii
- minimally invasive
- clinical trial
- ultrasound guided
- subarachnoid hemorrhage
- functional connectivity
- radiofrequency ablation
- blood brain barrier
- open label
- multiple sclerosis
- double blind
- placebo controlled