Concurrent transmission of multiple carbapenemases in a long-term acute-care hospital.
Danielle A RankinMaroya Spalding WaltersLuz CaicedoPaige GableHeather A Moulton-MeissnerAllison ChanAlbert BurksKendra EdwardsGillian McAllisterAlyssa G KentAlison S Laufer HalpinChristina MooreTracy McLemoreLinda ThomasNychie Q DotsonAlvina K ChuPublished in: Infection control and hospital epidemiology (2024)
Our response to a single patient colonized with VIM-CRPA and KPC-CRE identified concurrent CPO outbreaks at LTACH A. Epidemiologic and genomic investigations indicated that the observed diversity was due to a combination of multiple introductions of VIM-CRPA and KPC-CRE and to the transfer of carbapenemase genes across different bacteria species and strains. Improved infection control, including interventions that minimized potential spread from wastewater premise plumbing, stopped transmission.
Keyphrases
- klebsiella pneumoniae
- acute care
- escherichia coli
- multidrug resistant
- locally advanced
- case report
- healthcare
- genome wide
- copy number
- wastewater treatment
- drug resistant
- squamous cell carcinoma
- emergency department
- dna methylation
- gram negative
- human health
- acinetobacter baumannii
- radiation therapy
- transcription factor
- anaerobic digestion
- genetic diversity