Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk.
Annelie JohanssonDomenico PalliGiovanna MasalaSara GrioniClaudia AgnoliRosario TuminoMaria Concetta GiurdanellaFrancesca FasanelliCarlotta SacerdoteSalvatore PanicoAmalia MattielloSilvia PolidoroMichael E JonesMinouk J SchoemakerNick OrrKatarzyna TomczykNichola JohnsonOlivia FletcherVittorio PerducaLaura BagliettoPierre-Antoine DuguéMelissa C SoutheyGraham G GilesDallas R EnglishRoger L MilneGianluca SeveriSrikant AmbatipudiCyrille CueninVeronique ChajèsIsabelle RomieuZdenko HercegAnthony J SwerdlowPaolo VineisJames M FlanaganPublished in: Clinical epigenetics (2019)
We have identified a blood DNA methylation signature associated with breast cancer risk in this study. Further investigation is required to confirm the interaction between estrogen exposure and DNA methylation in the blood.