Genetic Profiling of Colorectal Carcinomas of Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease.
Manon de KrijgerBeatriz CarvalhoChristian RauschAnne S BolijnPien M Delis-van DiemenMarianne TijssenManon van EngelandNahid MostafaviRoel M M BogieEvelien DekkerAd A M MascleeJoanne VerheijGerrit A MeijerCyriel Y PonsioenPublished in: Inflammatory bowel diseases (2022)
The excess risk of CRC in patients with PSC-IBD was not explained by copy number aberrations, mutations, MSI, nor CIMP status, in cancer tissue, nor in adjacent mucosa. These findings set the stage for further exome-wide and epigenetic studies.