Multi-parametric cardiovascular magnetic resonance with regadenoson stress perfusion is safe following pediatric heart transplantation and identifies history of rejection and cardiac allograft vasculopathy.
Nazia HusainKae WatanabeHaben BerhaneAditi GuptaMichael MarklCynthia K RigsbyJoshua D RobinsonPublished in: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2021)
In a PHT population with low incidence of rejection or high-grade CAV, CMR demonstrates important differences in myocardial structure, function and perfusion compared to age-matched healthy controls. Regadenoson stress perfusion CMR could be safely and reliably performed. Increasing T2 values were associated with worsening left ventricular function and increasing T1/ECV values were associated with rejection history and low-grade CAV. These findings warrant larger prospective studies to further define the role of CMR in PHT graft surveillance.
Keyphrases
- low grade
- high grade
- left ventricular
- contrast enhanced
- magnetic resonance
- public health
- hypertrophic cardiomyopathy
- acute myocardial infarction
- cardiac resynchronization therapy
- magnetic resonance imaging
- mitral valve
- computed tomography
- risk factors
- left atrial
- genome wide
- coronary artery disease
- gene expression
- heat stress
- atrial fibrillation
- kidney transplantation
- case control