Angiotensin-(1-7) exerts a protective action in a rat model of ventilator-induced diaphragmatic dysfunction.
Vanessa ZambelliAnna SigurtàLaura RizziLetizia ZuccaPaolo DelvecchioElena BrescianiAntonio TorselloGiacomo BellaniPublished in: Intensive care medicine experimental (2019)
Systemic Ang-(1-7) administration during MV exerts a protective role on the muscular fibers of the diaphragm preserving muscular fibers anatomy, and reducing atrophy. The involvement of Mas and AT2R in the mechanism of action of Ang-(1-7) still remains controversial.