Angiotensin-(1-7) exerts a protective action in a rat model of ventilator-induced diaphragmatic dysfunction.

Vanessa ZambelliAnna SigurtàLaura RizziLetizia ZuccaPaolo DelvecchioElena BrescianiAntonio TorselloGiacomo Bellani

Published in: Intensive care medicine experimental (2019)

Systemic Ang-(1-7) administration during MV exerts a protective role on the muscular fibers of the diaphragm preserving muscular fibers anatomy, and reducing atrophy. The involvement of Mas and AT2R in the mechanism of action of Ang-(1-7) still remains controversial.

Keyphrases

angiotensin ii
mechanical ventilation
angiotensin converting enzyme

resistance training
high glucose
diabetic rats

oxidative stress
acute respiratory distress syndrome
drug induced

body composition
endothelial cells
extracorporeal membrane oxygenation