Significant anti-inflammatory aziridine-containing indole alkaloids from the Chinese medicinal plant Alstonia scholaris .
Bin-Yuan HuYun-Li ZhaoZhong-Shun ZhouYan-Yan ZhuXiao-Dong LuoPublished in: Chemical communications (Cambridge, England) (2023)
Two unique windmill-like aziridine-containing indole alkaloids, possessing an unprecedented 6/5/5/6/6/5/3 rigid ring system and an unusual azabicyclo[3.1.0]hexane core, were isolated from Alstonia scholaris . Their structures were established by spectroscopy, X-ray diffraction, and electronic circular dichroism calculations. The novel compounds exhibited significant anti-inflammatory bioactivity in vitro and alleviated LPS-induced acute lung injury in mice.
Keyphrases
- lps induced
- anti inflammatory
- high resolution
- inflammatory response
- lipopolysaccharide induced
- density functional theory
- electron microscopy
- molecular dynamics simulations
- high fat diet induced
- single molecule
- mass spectrometry
- magnetic resonance
- metabolic syndrome
- adipose tissue
- computed tomography
- skeletal muscle
- crystal structure
- monte carlo
- plant growth
- recombinant human