Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation.
Juan D Botero BSantiago Bernal-MacíasCarlos A Celis PJavier I Lasso AJorge RodríguezLiliana Arias ÁlvarezCatalina GonzalezKateir M ContrerasDaniel G Fernández-ÁvilaPublished in: Lupus (2022)
The coexistence of systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) as an overlapping syndrome is not common. Here, we report a case of a 33-year-old woman, with recent SLE diagnosis due to skin, kidney, articular, and immunologic compromise, in whom a chest CT scan showed bilateral nodules, consolidations, and tree-in-bud pattern; thoracoscopic lung biopsy revealed diffuse non-caseating granulomas, without other features of sarcoid, organizing pneumonia, or hypersensitivity pneumonitis with high positive p-ANCA titers. Overlap between SLE and AAV was a possible explanation for lupus granulomatous pneumonitis, and for this reason, a multidisciplinary meeting was held to evaluate complex patients with interstitial lung diseases patients.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- computed tomography
- interstitial lung disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- gene therapy
- case report
- peritoneal dialysis
- systemic sclerosis
- dual energy
- magnetic resonance
- contrast enhanced
- soft tissue
- image quality
- robot assisted
- mechanical ventilation
- thoracic surgery