The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin.
S BotticelliR ChiaraluceV ConsalviG La PennaA PasquoM PetrosinoO ProuxG C RossiF StellatoSilvia MorantePublished in: European physical journal plus (2023)
In this paper, we provide evidence that Zn 2 + ions play a role in the SARS-CoV-2 virus strategy to escape the immune response mediated by the BST2-tetherin host protein. This conclusion is based on sequence analysis and molecular dynamics simulations as well as X-ray absorption experiments [1].
Keyphrases
- sars cov
- molecular dynamics simulations
- immune response
- respiratory syndrome coronavirus
- heavy metals
- amino acid
- protein protein
- quantum dots
- molecular docking
- high resolution
- binding protein
- aqueous solution
- dendritic cells
- magnetic resonance
- computed tomography
- small molecule
- risk assessment
- water soluble
- mass spectrometry
- inflammatory response
- coronavirus disease
- contrast enhanced