Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b.

Mariavittoria D'Acierno Roberta Resaz Anna IervolinoRikke NielsenDonato SardellaSabrina SiccardiVincenzo CostanzoLuciano D'ApolitoYoko SuzumotoDaniela SegalerbaSimonetta AstigianoAlessandra F PernaGiovambattista Capasso Alessandra Eva Francesco Trepiccione

Published in: Journal of the American Society of Nephrology : JASN (2022)

We provide proof of concept for the efficacy of dapagliflozin in preserving kidney function in GSD1b mice. Our findings could represent the basis for repurposing this drug to treat patients with GSD1b.

Keyphrases

mouse model
single cell
cell therapy
high fat diet induced
emergency department
adipose tissue
drug induced
insulin resistance
skeletal muscle