Biomineralization-inspired synthesis of amorphous manganese phosphates for GLUT5-targeted drug-free catalytic therapy of osteosarcoma.
Chun-Lin ZhangJianping HuYingying JiangShuo TanKunpeng ZhuChao XueYulun DaiFeng ChenPublished in: Nanoscale (2022)
Osteosarcoma, occurring most frequently in children, teens, and young adults, is a lethal bone cancer with a high incidence of distant metastases and drug resistance. Developing a therapeutic platform that integrates targeting, curing and imaging is highly desirable for enhanced osteosarcoma therapy, yet quite challenging. In this work, we demonstrate a novel biomineralization-inspired strategy for the synthesis of a fructose incorporated manganese phosphate (Fru-MnP) nanoplatform for tumour targeting, drug-free therapy, and MRI imaging. Benefitting from the glucose transporter 5 (GLUT5)-mediated endocytosis, our Fru-MnP nanoplatform produces a high level of reactive oxygen species (ROS) via the Mn 2+ -driven Fenton reaction within osteosarcoma cells, leading to efficient cancer cell killing due to caspase-mediated apoptosis. By virtue of the T1 signal enhancement of Mn 2+ , our Fru-MnP nanoplatform also acts as an effective tumour-specific MRI contrast agent, realizing the MRI-monitored chemodynamic therapy. The proposed synergistic therapeutic platform opens new possibilities for high efficacy therapy for osteosarcoma.
Keyphrases
- cancer therapy
- young adults
- reactive oxygen species
- contrast enhanced
- magnetic resonance imaging
- photodynamic therapy
- high resolution
- induced apoptosis
- cell death
- drug delivery
- lymph node
- diffusion weighted imaging
- risk factors
- blood pressure
- oxidative stress
- computed tomography
- metabolic syndrome
- room temperature
- cell therapy
- cell cycle arrest
- bone marrow
- body composition
- endoplasmic reticulum stress
- ionic liquid
- postmenopausal women
- insulin resistance
- pi k akt