Pharmacokinetics of Phenprocoumon in Emergency Situations-Results of the Prospective Observational RADOA-Registry (Reversal Agent Use in Patients Treated with Direct Oral Anticoagulants or Vitamin K Antagonists Registry).
Edelgard Lindhoff-LastIngvild BirschmannAntonia J BidenharnJoachim KuhnSimone LindauStavros KonstantinidesOliver GrottkeUlrike Nowak-GöttlJessica LucksBarbara ZydekChristian von HeymannAriane SümnigJan Beyer-WestendorfSebastian SchellongPatrick MeybohmAndreas GreinacherEva Herrmannnull nullPublished in: Pharmaceuticals (Basel, Switzerland) (2022)
In emergency situations, the long half-life of phenprocoumon may cause INR rebound and associated recurrent bleedings. Optimal management may need to include repeated vitamin K supplementation over days.