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Pharmacokinetics of Phenprocoumon in Emergency Situations-Results of the Prospective Observational RADOA-Registry (Reversal Agent Use in Patients Treated with Direct Oral Anticoagulants or Vitamin K Antagonists Registry).

Edelgard Lindhoff-LastIngvild BirschmannAntonia J BidenharnJoachim KuhnSimone LindauStavros KonstantinidesOliver GrottkeUlrike Nowak-GöttlJessica LucksBarbara ZydekChristian von HeymannAriane SümnigJan Beyer-WestendorfSebastian SchellongPatrick MeybohmAndreas GreinacherEva Herrmannnull null
Published in: Pharmaceuticals (Basel, Switzerland) (2022)
In emergency situations, the long half-life of phenprocoumon may cause INR rebound and associated recurrent bleedings. Optimal management may need to include repeated vitamin K supplementation over days.
Keyphrases
  • direct oral anticoagulants
  • venous thromboembolism
  • public health
  • emergency department
  • atrial fibrillation
  • healthcare
  • emergency medical