Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction.
Nannan ZhangBin FengXuexing MaKangyun SunGuidong XuYafeng ZhouPublished in: Cardiovascular diabetology (2019)
9 weeks of dapagliflozin treatment decreases hypertension and reverses LV concentric remodeling in HFpEF pigs partly by restraining sympathetic tone in the aorta, leading to inhibition of the inflammatory response and NO-cGMP-PKG pathway activation.
Keyphrases
- inflammatory response
- left ventricular
- aortic valve
- pulmonary artery
- blood pressure
- nitric oxide
- heart failure
- lipopolysaccharide induced
- aortic stenosis
- coronary artery
- coronary artery disease
- acute myocardial infarction
- lps induced
- transcatheter aortic valve replacement
- atrial fibrillation
- percutaneous coronary intervention
- acute coronary syndrome
- replacement therapy
- smoking cessation