P2X7 receptor inhibition prevents atrial fibrillation in rodent models of depression.
Tianxin YeYunping ZhouJinxiu YangFangcong YuZhuonan SongJiaran ShiLongbo WangZhou-Qing HuangBo YangXingxiang WangPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)
LPS or CUS induces AF and promotes P2X7R-dependent activation of NLRP3 inflammasome, whereas pharmacological P2X7R inhibition or P2X7R genetic deficiency prevents atrial remodelling without interrupting normal atrial physiological functions. Our results point to P2X7R as an important factor in the pathology of AF in depression.
Keyphrases
- atrial fibrillation
- nlrp inflammasome
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- depressive symptoms
- direct oral anticoagulants
- heart failure
- sleep quality
- percutaneous coronary intervention
- genome wide
- gene expression
- dna methylation
- anti inflammatory
- copy number
- coronary artery disease
- acute coronary syndrome