DNA Repair Pathways and Their Association With Lethal Prostate Cancer in African American and European American Men.
Anna PlymMiklos DiossyZoltan SzallasiOliver SartorJonathan SilbersteinIsaac J PowellTimothy R RebbeckKathryn L PenneyLorelei A MucciMark M PomerantzAdam S KibelPublished in: JNCI cancer spectrum (2021)
Our findings suggest that altered DDR is an important mechanism for aggressive prostate cancer not only in men of European but also of African ancestry. Therefore, interrogation of entire DDR pathways is needed to fully characterize and better define genetic risk of lethal disease.