Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats.
Yuchun ZuoLei HuangBudbazar EnkhjargalWeilin XuOcak UmutZachary D TravisGuangyu ZhangJiping TangFei LiuArne P NeyrinckPublished in: Journal of neuroinflammation (2019)
The activation of RXR by bexarotene attenuated neuroinflammation and improved neurological deficits after SAH. The anti-neuroinflammatory effect was at least partially through regulating PPARγ/SIRT6/FoxO3a pathway. Bexarotene may be a promising therapeutic strategy in the management of SAH patients.
Keyphrases
- subarachnoid hemorrhage
- cerebral ischemia
- brain injury
- traumatic brain injury
- end stage renal disease
- transcription factor
- ejection fraction
- lipopolysaccharide induced
- newly diagnosed
- chronic kidney disease
- signaling pathway
- oxidative stress
- insulin resistance
- lps induced
- prognostic factors
- ischemia reperfusion injury
- peritoneal dialysis
- blood brain barrier
- inflammatory response
- skeletal muscle