Stereoselective Copper-Catalyzed Direct Aldol Reaction of β, γ-Unsaturated α-Ketoesters with Coumaran-3-Ones.
Kuiliang LiXiang SunLinge LiZhenggen ZhaFeng-Lian ZhangZhiyong WangPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
An efficient direct aldol reaction between coumaran-3-ones and β, γ-unsaturated α-ketoesters by virtue of a chiral copper complex is developed. A series of coumaran-3-one derivatives containing chiral tertiary alcohol structures are obtained in excellent yields and stereoselectivities.