Metal-Free C-H Sulfamidation of 1,4-Naphthoquinone in Water.

Direct sulfamidation of 1,4-naphthoquinones using N -methoxy sulfonamides under metal-free conditions in water was developed. Base-mediated nucleophilic addition of N -methoxy sulfonamides, followed by N-O bond cleavage allowed the formation of enesulfonamides. Further, the synthesis of pyrrolonaphthoquinones proved the practicability of the current approach.