High salt induces cognitive impairment via the interaction of angiotensin II-AT1 and prostaglandin E2-EP1 systems.

Hisayoshi KubotaKazuo KunisawaBolati WulaerMasaya HasegawaHitomi KurahashiTakatoshi SakataHiroyuki TezukaMasanori KugitaShizuko NagaoTaku NagaiTomoyuki FuruyashikiShuh NarumiyaKuniaki SaitoToshitaka NabeshimaAkihiro Mouri

Published in: British journal of pharmacology (2023)

Our findings suggest that the interaction of Ang II-AT1 and PGE2-EP1 systems could be novel therapeutic targets for hypertension-induced cognitive impairment.

Keyphrases

angiotensin ii
cognitive impairment
angiotensin converting enzyme
vascular smooth muscle cells
blood pressure
diabetic rats
high glucose
drug induced
oxidative stress