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Outcomes of Cardiac Contractility Modulation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Ramy MandoAkshay GoelFuad J HabashMarwan SaadKaram AyoubSrikanth VallurupalliWaddah Maskoun
Published in: Cardiovascular therapeutics (2019)
Short-term treatment with CCM may improve MLFHQ without significant difference in 6MWD, arrhythmic events, HF hospitalizations, all-cause hospitalizations, and all-cause mortality. There is a trend towards increased pacemaker/ICD device malfunction. Larger RCTs might be needed to determine if the CCM therapy will be beneficial with longer follow-up.
Keyphrases
  • left ventricular
  • clinical trial
  • type diabetes
  • metabolic syndrome
  • smooth muscle
  • adipose tissue
  • combination therapy
  • skeletal muscle
  • acute heart failure
  • pulmonary embolism
  • replacement therapy
  • cell therapy