Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis.

Ji ZhuHang ChenJianan GuoChen ZhaDezhao Lu

Published in: Journal of inflammation research (2022)

Our results suggest that STS enhances maintenance of mitochondrial homeostasis and inhibits mitochondrial ROS overproduction via AMPK, thereby improving endothelial cell pyroptosis during AS.

Keyphrases

endothelial cells
signaling pathway
oxidative stress
nlrp inflammasome
skeletal muscle
cardiovascular disease
protein kinase
cell death
high glucose
pi k akt
epithelial mesenchymal transition
reactive oxygen species
type diabetes
endoplasmic reticulum stress