Genetic regulation of gene expression and splicing during a 10-year period of human aging.
Brunilda BalliuMatthew DurrantOlivia de GoedeNathan AbellXin LiBoxiang LiuMichael J GloudemansNaomi L CookKevin S SmithDavid A KnowlesMauro PalaFrancesco CuccaDavid SchlessingerSiddhartha JaiswalChiara SabattiLars LindErik IngelssonStephen B MontgomeryPublished in: Genome biology (2019)
These findings demonstrate that, although the transcriptome and its genetic regulation is mostly stable late in life, a small subset of genes is dynamic and is characterized by a reduction in genetic regulation, most likely due to increasing environmental variance with age.