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Characterization of proinsulin-specific regulatory T cells in type 1 diabetes at different ages of onset.

Mahinder PaulDevi DayalAnil BhansaliNaresh Sachdeva
Published in: Pediatric diabetes (2019)
Unlike polyclonal Tregs, both T1D subtypes harbor comparable frequencies of PI-specific Tregs. Chronic antigen presentation results in a distinct memory-like phenotype of PI-specific Tregs in these subjects irrespective of the age of disease onset.
Keyphrases
  • regulatory t cells
  • type diabetes
  • dendritic cells
  • cardiovascular disease
  • immune response
  • insulin resistance
  • skeletal muscle
  • weight loss