Characterization of proinsulin-specific regulatory T cells in type 1 diabetes at different ages of onset.
Mahinder PaulDevi DayalAnil BhansaliNaresh SachdevaPublished in: Pediatric diabetes (2019)
Unlike polyclonal Tregs, both T1D subtypes harbor comparable frequencies of PI-specific Tregs. Chronic antigen presentation results in a distinct memory-like phenotype of PI-specific Tregs in these subjects irrespective of the age of disease onset.