Gene Expression Meta-Analysis of Cerebellum Samples Supports the FKBP5 Gene-Environment Interaction Model for Schizophrenia.
Libi HertzbergAda H ZoharAssif YitzhakyPublished in: Life (Basel, Switzerland) (2021)
Our results give significant support to the FKBP5 gene-environment interaction model for schizophrenia, which provides a molecular mechanism by which childhood adversity is involved in the development of the disorder. To explore FKBP5's potential as a therapeutic target, a mapping of its differential expression patterns in different brain regions of schizophrenia patients is needed.
Keyphrases
- bipolar disorder
- gene expression
- systematic review
- end stage renal disease
- newly diagnosed
- ejection fraction
- copy number
- chronic kidney disease
- dna methylation
- peritoneal dialysis
- early life
- prognostic factors
- genome wide identification
- meta analyses
- patient reported outcomes
- resting state
- transcription factor
- risk assessment
- human health