Maturity of circulating antibody-secreting cells is associated with disease features in primary Sjögren's syndrome.

Numbers and maturation stage of ASCs in pSS patients are increased and correlate with disease parameters. A higher maturity index of ASCs marks a pro-survival and pro-inflammatory phenotype. Altogether, B cell hyperactivity in pSS extends to the peripheral ASC compartment raising potential for ASCs as future biomarker or target for pSS treatment. This article is protected by copyright. All rights reserved.