Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior.

Elisabeth G VichayaPhillip S GrossDarlene J EstradaSteve W ColeAaron J GrossbergScott E EvansMichael J TuvimBurton F DickeyRobert Dantzer

Published in: Psychopharmacology (2019)

Our data demonstrate that lcn2 is dispensable for sterile inflammation-induced sickness and depression-like behavior. Specifically, lcn2-/- mice displayed sickness and immobility in the tail suspension test comparable to that of WT mice both in terms of intensity and duration.

Keyphrases

oxidative stress
diabetic rats
high glucose
depressive symptoms
high fat diet induced
drug induced
type diabetes
electronic health record
endothelial cells
machine learning
big data
insulin resistance
skeletal muscle
artificial intelligence