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Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.

Elena Juárez-BarberAna CorachánMaría Cristina Carbajo-GarcíaAmparo FausCarmen VidalJuan GilesAntonio PellicerIrene CervellóHortensia Ferrero
Published in: Reproductive biology and endocrinology : RB&E (2024)
Identifying dysregulated molecular mechanisms in mid-secretory and gestational endometrium of adenomyosis women contributes to the understanding of adenomyosis-related implantation failure and/or pregnancy disorders revealing potential therapeutic targets. Following experimental validation of our transcriptomic and in silico findings, our differentiated adenomyosis patient-derived organoids have the potential to provide a reliable platform for drug discovery, development, and personalized drug screening for affected patients.
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