Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.
Elena Juárez-BarberAna CorachánMaría Cristina Carbajo-GarcíaAmparo FausCarmen VidalJuan GilesAntonio PellicerIrene CervellóHortensia FerreroPublished in: Reproductive biology and endocrinology : RB&E (2024)
Identifying dysregulated molecular mechanisms in mid-secretory and gestational endometrium of adenomyosis women contributes to the understanding of adenomyosis-related implantation failure and/or pregnancy disorders revealing potential therapeutic targets. Following experimental validation of our transcriptomic and in silico findings, our differentiated adenomyosis patient-derived organoids have the potential to provide a reliable platform for drug discovery, development, and personalized drug screening for affected patients.
Keyphrases
- pregnancy outcomes
- drug discovery
- end stage renal disease
- preterm birth
- ejection fraction
- pregnant women
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- weight gain
- polycystic ovary syndrome
- prognostic factors
- type diabetes
- adipose tissue
- molecular docking
- skeletal muscle
- drug induced
- human health
- patient reported outcomes
- physical activity
- climate change
- body mass index