TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India.

Narinder GroverPrateek BhatiaAntriksh KumarMinu SinghDeepesh LadHarshal S MandavdhareJayanta SamantaKaushal K PrasadUsha DuttaNavneet Sharma

Published in: BMC gastroenterology (2021)

NUDT15 polymorphism was more frequent than TPMT polymorphisms and was associated with thiopurine induced leukopenia. However, the tested polymorphisms account for only 24.2% of the risk of thiopurine induced leukopenia.

Keyphrases

high glucose
diabetic rats
oxidative stress
endothelial cells