Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance.
Yuri A BlednovAdriana J Da CostaRobert Adron HarrisRobert O MessingPublished in: Alcoholism, clinical and experimental research (2018)
Our results suggest that apremilast increases the duration of EtOH intoxication by reducing AFT. Apremilast also reduces some aspects of general reward and increases EtOH's aversive properties, which might also contribute to its ability to reduce EtOH drinking.