Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells.

Published in: PloS one (2017)

The depletion of claudin-2, occludin and ZO-1 in HK-2 cells had differential effects on TER and macromolecule flux. We demonstrated that integration of claudin-2, occludin and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.

Keyphrases

induced apoptosis
cell cycle arrest
high glucose
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell death
pi k akt