Effect of BRCA1 on the Concurrent Chemoradiotherapy Resistance of Cervical Squamous Cell Carcinoma Based on Transcriptome Sequencing Analysis.
Xin WenShui LiuManhua CuiPublished in: BioMed research international (2020)
BRCA1 overexpression in SiHa cells may upregulate STAT1 to activate the JAK/STAT signaling pathway, suggesting a mechanism for enhanced CCRT resistance.
Keyphrases
- locally advanced
- induced apoptosis
- squamous cell carcinoma
- signaling pathway
- single cell
- cell proliferation
- cell cycle arrest
- rectal cancer
- pi k akt
- rna seq
- endoplasmic reticulum stress
- gene expression
- breast cancer risk
- genome wide
- epithelial mesenchymal transition
- oxidative stress
- radiation therapy
- lymph node metastasis
- cell death
- dna methylation