Syngeneic red blood cell-induced extracellular vesicles suppress delayed-type hypersensitivity to self-antigens in mice.
Katarzyna NazimekEugenio Bustos-MoránNoelia Blas-RusBernadeta NowakWłodzimierz PtakPhillip W AskenaseFrancisco Sánchez-MadridKrzysztof BryniarskiPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
The current study describes a newly discovered mechanism of self-tolerance induced by the intravenous delivery of a high dose of sMRBC that is mediated by EVs in a miRNA-150-dependent manner. This mechanism implies the concept of naturally occurring immune tolerance, presumably activated by overloading of the organism with altered self-antigens.