Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.

Di-Zheng WuGuo-Zheng ZhuKai ZhaoJia-Wen GaoGui-Xing CaiHong-Zhou LiYu-Sheng HuangChen TuJing-Shen ZhuangZhi-Wei HuangZhao-Ming Zhong

Published in: Molecular medicine (Cambridge, Mass.) (2024)

These results suggest that age-related decline of MT enhanced osteoclastogenesis via disruption of redox homeostasis. MT may serve as a key regulator in osteoclastogenesis and bone homeostasis, thereby highlighting its potential as a preventive agent for age-related bone loss.

Keyphrases

bone loss
transcription factor
inflammatory response
body composition
electron transfer