PD-1 blockade synergizes with intratumoral vaccination of a therapeutic HPV protein vaccine and elicits regression of tumor in a preclinical model.

Shiwen PengMarietta TanYen-Der LiMax A ChengEmily FarmerLouise FerrallStephanie GaillardRichard B S RodenChien-Fu HungT -C Wu

Published in: Cancer immunology, immunotherapy : CII (2020)

Our results provide rationale for future clinical testing of intratumoral TA-CIN vaccination in combination with PD-1 blockade for the control of HPV16-associated tumors.

Keyphrases

high grade
cervical cancer screening
current status
clinical trial
protein protein
cell therapy
amino acid
stem cells
binding protein
small molecule