Protective effects of a SIRT1 inhibitor on primordial follicle activation and growth induced by cyclophosphamide: insights from a bovine in vitro folliculogenesis system.

Giovanna Di Emidio Carla TatoneVincenza BarbatoVincenzo GenoveseMartina Placidi Riccardo Talevi Roberto Gualtierinull null

Published in: Journal of assisted reproduction and genetics (2022)

SIRT1 can represent a candidate molecule to be targeted to protect ovarian follicles from alkylating agents and EX-527 could represent a potential fertoprotective agent for cancer patients.

Keyphrases

oxidative stress
ischemia reperfusion injury
low dose
high dose
cancer therapy
human health
drug delivery
climate change