Proteome and Structural Organization of the Knob Complex on the Surface of the Plasmodium Infected Red Blood Cell.

This study provides structural insight into the organization of the core knob components and uncovers novel proteins as knob components. This structural information can be used for the development of better vaccine design strategies or drug design to destabilize the knob structure, which is a major virulence determinant in P. falciparum malaria.