IL-6 signaling in macrophages is required for immunotherapy-driven regression of tumors.
Elham Beyranvand NejadCamilla LabrieMarit J van ElsasJan Willem KleinovinkHans-Willi MittrückerKees L M C FrankenSylvia HeinkThomas KornRamon ArensThorbald van HallSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2021)
IL-6 signaling is critical for macrophage function under circumstances of immunotherapy-induced tumor tissue destruction, in line with the acute inflammatory functions of IL-6 signaling described in infections.