Peri-mortem rigidity in a fatal case of severe salicylate poisoning.

Oyeyimika OyekanmiCatherine DongBrandon K WillsKirk L Cumpston

Published in: Clinical toxicology (Philadelphia, Pa.) (2024)

We hypothesize that in our patient, rapid-occurring rigor mortis likely resulted from depletion of adenosine triphosphate. This occurred as a result of uncoupling of oxidative phosphorylation in the mitochondria from severe salicylate poisoning, as adenosine triphosphate is required for muscle relaxation.

Keyphrases

protein kinase
early onset
skeletal muscle
case report
cell death
drug induced
nitric oxide
endoplasmic reticulum