The effect of hematopoietic stem cell transplantation on fertility and strategies for improvement.
Brittany FileMia GergisUsama GergisPublished in: Bone marrow transplantation (2022)
Ovarian dysfunction is an important consequence of hematopoietic stem cell transplantation (HCT). Premature ovarian failure and infertility can severely impact the quality of life for the increasing number of female long-term survivors of HCT. Here, we review the impact of HCT on ovarian function, post-transplant fertility and birth outcomes, and the contemporaneous strategies to preserve fertility for these patients.
Keyphrases
- end stage renal disease
- acute myeloid leukemia
- cell cycle arrest
- newly diagnosed
- childhood cancer
- young adults
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- oxidative stress
- cell death
- metabolic syndrome
- pregnant women
- gestational age
- pregnancy outcomes
- patient reported
- polycystic ovary syndrome
- pi k akt
- preterm birth