Ca2+ Induced Crosslinking of AIE-Active Polyarylene Ether Nitrile into Fluorescent Polymeric Nanoparticles for Cellular Bioimaging.
Pan WangKun JiaXuefei ZhouXiaotian GuanLianhui WangYuan TianChunhui WuXiaobo LiuPublished in: Macromolecular rapid communications (2017)
Biocompatible fluorescent polymeric nanoparticles (FPNs) are promising luminescent probes in cellular bioimaging, while the fabrication of high-quantum-yield FPN using nonconjugated heterochain polymers derived from step-growth polymerization is still in its infancy. Herein, the nonconjugated polyarylene ether nitrile (PEN) is endowed with aggregation-induced emission (AIE) feature by incorporation of an AIEgen named of 1,2-di(4-hydroxyphenyl)-1,2-diphenylethene into macromolecular backbone. Furthermore, the AIE-active PEN is crosslinked into water soluble fluorescent nanospheres showing good biocompatibility and strong emission ≈480 nm with a quantum yield of 21% in the presence of Ca2+ , which allows the successful bioimaging of cancer cells. Due to the facile fabrication of FPNs and their effective bioimaging performance, the current work will open the way for the biomedical applications of various high performance polyarylene ethers.
Keyphrases
- living cells
- fluorescent probe
- quantum dots
- water soluble
- single molecule
- drug release
- drug delivery
- energy transfer
- ionic liquid
- molecular dynamics
- cancer therapy
- tissue engineering
- machine learning
- minimally invasive
- photodynamic therapy
- metal organic framework
- deep learning
- high glucose
- diabetic rats
- low cost
- protein kinase
- gold nanoparticles
- small molecule
- reduced graphene oxide
- monte carlo
- solid state
- fluorescence imaging