In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.
Patrick J O'DwyerChara LitouKarl J BoxJennifer B DressmanEdmund S KostewiczMartin KuentzChristos ReppasPublished in: The Journal of pharmacy and pharmacology (2018)
Despite the progress from compendial quality control dissolution methods, further work is required to validate the usefulness of proposed setups and to increase their biorelevance, particularly in simulating the absorption of drug along the intestinal lumen. Coupling results from in vitro testing with physiologically based pharmacokinetic modelling holds significant promise and requires further evaluation.