Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery.
Marialuisa de CegliaMaria Vittoria Micioni Di BonaventuraAdele RomanoMarzia FriuliEmanuela Micioni Di BonaventuraAna L GavitoLuca BotticelliSilvana GaetaniFernando Rodríguez de FonsecaCarlo CifaniPublished in: The International journal of eating disorders (2023)
The present study focused on evaluating the role of the endocannabinoid system in modulating withdrawal from naturally rewarding activities that have an impact on mood, such as feeding. The variations observed in the emotional behavior of abstinent rats was linked to neuroadaptations of the ECS in specific brain areas.