Incidence and management of patients with methotrexate delayed elimination in the clinical practice: A Delphi study.
Luis GrosAlicia Roldán PérezAlmudena Cabero-MartínezNerea Domínguez-PinillaAdolfo de la FuenteEva González-BarcaMaría TassoMontserrat TorrentEva GallardoInés Del CerroAriadna Giró-PerafitaXavier BadiaPublished in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2022)
These results are the first evidence regarding HDMTX-induced AKI in Spain. Incidence and mortality results are in line with previous studies. Clinical management is based on preventive measures and the treatment depend on the availability in the hospital. The need for effective, safe and rapid treatment for the reduction of MTX toxic levels and the improvement of monitoring methods were noted by experts as urgent needs. Further observational studies to validate these results would be needed.