Association of β-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals.
Laura M van der KallThanh TruongSamantha C BurnhamVincent DoréRachel S MulliganSvetlana BozinovskiFiona LambPierrick BourgeatJurgen FrippStephanie SchultzYen Y LimSimon M LawsDavid AmesChristopher FowlerStephanie R Rainey-SmithRalph N MartinsOlivier SalvadoJoanne RobertsonPaul MaruffColin L MastersVictor L VillemagneChristopher C RowePublished in: Neurology (2020)
The risk of MCI or dementia over 5 years in older CN is related to Aβ level on PET, 5% if negative vs 25% if positive but ranging from 12% if 26-50 CL to 28% if 51-100 CL and 50% if >100 CL. This information may be useful for dementia risk counseling and aid design of preclinical AD trials.