Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?

Yi LiuXiaojun ChenHuaiwu LuXin WuXuehan LiuFei XuDongdong YeBo DingXiaoyan LuLing QiuJing ZhuYingying WangXinya HuangZhen ShenTao ZhuYang ShenYing Zhou

Published in: Molecular diagnosis & therapy (2024)

This study provides evidence that 15-gene panel HRRm can predict the prognosis of EOC, of these only the BRCA1/2 mutations, not non-BRCA HRRm, contribute to prognosis prediction. Among patients without PARPis, the HRRm group presented a better PFS. This is the first study of this kind in the Chinese population.

Keyphrases

copy number
gene expression
oxidative stress
dna methylation
genome wide identification
genome wide analysis