Zataria multiflora and its constituent, carvacrol, counteract sepsis-induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress.
Mahmoud HosseiniZohreh ArabFarimah BeheshtiAkbar AnaeigoudariFarzaneh ShakeriArezoo RajabianPublished in: Animal models and experimental medicine (2023)
The results suggest protective effects of ZME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO production. However, additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.
Keyphrases
- lps induced
- oxidative stress
- inflammatory response
- diabetic rats
- nitric oxide
- left ventricular
- high glucose
- dna damage
- ischemia reperfusion injury
- acute kidney injury
- induced apoptosis
- aortic valve
- septic shock
- intensive care unit
- nitric oxide synthase
- hydrogen peroxide
- heart failure
- drug induced
- heat shock
- anti inflammatory
- aortic dissection