Anti-inflammatory, Anti-fibrotic and Pro-cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR-1 and miR-199a on Human Cardiac Fibroblasts.

Katarzyna Kmiotek-WasylewskaSylwia Bobis-WozowiczElżbieta KarnasMonika OrpelOlga WoźnickaZbigniew MadejaBuddhadeb DawnEwa K Zuba-Surma

Published in: Stem cell reviews and reports (2023)

hiPS-EVs carrying miR-1 and miR-199a attenuate apoptosis and pro-fibrotic and pro-inflammatory activities of CFs, and increase cardiomyogenic gene expression. These finding serve as rationale for targeting fibroblasts with novel EV-based miRNA therapies to improve heart repair after myocardial injury.

Keyphrases

cell proliferation
long non coding rna
anti inflammatory
long noncoding rna
gene expression
endothelial cells
heart failure
oxidative stress
dna methylation
clinical trial
cell death
cell cycle arrest