Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study.
Marieke J H BegemannMaya J L SchutteEdwin van DellenLucija AbramovicMarco P BoksNeeltje E M van HarenRene C W MandlChristiaan H VinkersMarc M BohlkenIris E C SommerPublished in: Psychological medicine (2021)
Findings show that childhood trauma is linked to frontal gray matter reductions, independent of psychiatric morbidity. Our results indicate that childhood trauma importantly contributes to the neurobiological changes commonly observed across psychiatric disorders. Frontal volume alterations may underpin affective and cognitive disturbances observed in trauma-exposed individuals.