Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs.

Kanbin WangChengwei ZhouLijun LiChengxin DaiZhongxiang WangWeijun ZhangJianxiang XuYueliang ZhuZhi-Jun Pan

Published in: Stem cell research & therapy (2022)

Our study demonstrates the dual effects of AU in not only promoting bone-fracture healing by regulating osteogenesis of hBM-MSCs partly via canonical BMP2/Smads signaling pathway but also suppressing oxidative stress damage partly via Nrf2/HO1 signaling pathway.

Keyphrases

signaling pathway
oxidative stress
mesenchymal stem cells
bone regeneration
pi k akt
induced apoptosis
bone mineral density
epithelial mesenchymal transition
umbilical cord
soft tissue
dna damage
diabetic rats
bone loss
hip fracture
transforming growth factor
body composition
cell proliferation
postmenopausal women