Phenotypic clustering of bipolar disorder supports stratification by lithium responsiveness over diagnostic subtypes.

Katie ScottClaire O'DonovanGiulio Emilio BrancatiPablo CervantesRafaella ArdauMirko ManchiaGiovanni SeverinoJanusz RybakowskiLeonardo TondoPaul GrofMartin Alda Abraham Nunes

Published in: Acta psychiatrica Scandinavica (2024)

Phenotypes derived from detailed clinical data may carry more information about lithium responsiveness than the current classification of diagnostic subtype. These findings support lithium responsiveness as a valid approach to stratification in clinical samples.

Keyphrases

bipolar disorder
solid state
machine learning
major depressive disorder
deep learning
healthcare
big data
single cell
social media
artificial intelligence